Brinzolamide-d5
- Product Name
- Brinzolamide-d5
- CAS No.
- 1217651-02-9
- Chemical Name
- Brinzolamide-d5
- Synonyms
- Brinzolamide-d5;[2H5]-Brinzolamide
- CBNumber
- CB32507883
- Molecular Formula
- C12H21N3O5S3
- Formula Weight
- 383.5
- MOL File
- 1217651-02-9.mol
Brinzolamide-d5 Property
- storage temp.
- Refrigerator
- solubility
- Ethanol
- form
- Solid
- color
- Crystalline
N-Bromosuccinimide Price
- Product number
- 30006
- Product name
- Brinzolamide-d5
- Packaging
- 500μg
- Price
- $279
- Updated
- 2024/03/01
- Product number
- 30006
- Product name
- Brinzolamide-d5
- Packaging
- 1mg
- Price
- $501
- Updated
- 2024/03/01
- Product number
- B677602
- Product name
- Brinzolamide-d5
- Packaging
- 5mg
- Price
- $1980
- Updated
- 2021/12/16
- Product number
- RDL0006690
- Product name
- BRINZOLAMIDE-D5
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $2783
- Updated
- 2021/12/16
- Product number
- 7669DG
- Product name
- Brinzolamide-d5
- Packaging
- 1mg
- Price
- $646
- Updated
- 2021/12/16
Brinzolamide-d5 Chemical Properties,Usage,Production
Description
Brinzolamide-d5 is intended for use as an internal standard for the quantification of brinzolamide by GC- or LC-MS. Brinzolamide is a potent inhibitor of carbonic anhydrase II (CAII) and CAIV (IC50s = 3.19 and 45.3 nM, respectively). It is selective for CAII and CAIV over CAI (IC50 = ~1,365 nM). Brinzolamide (30 mg/kg) reduces intestinal charcoal meal progression by 44% and prolongs pentobarbital sodium-induced sleep time by 35% in mice. Topical administration of brinzolamide (0.25, 0.5, and 1 mg/eye) reduces intraocular pressure in a rabbit model of spontaneous ocular hypertension. It also reduces intraocular pressure in a cynomolgus monkey model of argon laser trabeculoplasty-induced ocular hypertension. Formulations containing brinzolamide have been used in the treatment of glaucoma and ocular hypertension.
Chemical Properties
Crystalline Solid
Uses
Carbonic anhydrase inhibitor. Antiglaucoma agent.